Glucosamine Chondroitin and MSM combinations like this top seller from Doctor's Best have become the most widely used type of joint combination. Used together glucosamine, chondroitin and MSM produce more noticeable effects sooner than the old glucosamine-chondroitin formulas for about the same number and size of tablets you're taking each day. While all 3 of these nutrients are critical building blocks for joint tissue and cartilage, MSM provides the valuable nutrient mineral sulfur, which improves the health and vitality of skin, hair and nails, as well as your joints. Doctor's Best uses the premium Lignisul MSM ingredient and the clinically-proven doses of glucosamine (1500 mg) and chondroitin (1200 mg) in each daily dose.