NOW Foods Pantethine is our best-selling pantethine supplement. The pantethine form of vitamin B5 is an overlooked cholesterol-support nutrient, despite studies that show it can lower total and LDL cholesterol, lower triglycerides and raise beneficial HDL. Like any cholesterol-support, it doesn't work for everyone, but given its low cost and safety, pantethine is definitely worth trying for those who wish to explore all the natural cholesterol-support options available. Most people can get good results by systemically trying the many natural approaches like pantethine, niacin, fish oil and red yeast rice. Regular cholesterol tests under a doctor's supervision are necessary to evaluate the effective of pantethine or any other approach to cholesterol management. For best results, use the higher end of the dose range by taking 2 or 3 softgels daily.