NOW SAMe 400 mg is such a versatile and powerful nutrient that it's like 3 or 4 separate supplements in one. SAMe is a natural amino acid metabolite that supports brain health and a good mood, cardiovascular health, joint comfort, and is a potent liver detoxification factor. The ideal daily dose and dose schedule of SAMe varies from person. Most users are in the 200-2400 mg per day range in terms of amount, and SAMe is best taken on an empty stomach, either in divided doses or all at once. But with most SAMe tablet products only supplying 200 mg of SAMe, these high-potency NOW 400 mg SAMe tablets are a more practical choice for users on the high end of the range. We strongly recommend you take, at the least, a B-complex vitamin if you decide to use SAMe; the ideal B complex to use with SAMe is NOW's Homocysteine Regulator. These B-vitamin co-factors are necessary for your body to make full use of SAMe, but aren't supplied buy the SAMe tablets themselves.