NOW SAMe 400 mg is such a versatile and powerful nutrient that it's like 3 or 4 separate supplements in one. SAMe is a natural amino acid metabolite that supports brain health and a good mood, cardiovascular health, joint comfort, and is a potent liver detoxification factor. The ideal daily dose and dose schedule of SAMe varies from person. Most users are in the 200-2400 mg per day range in terms of amount, and SAMe is best taken on an empty stomach, either in divided doses or all at once. But with most SAMe tablet products only supplying 200 mg of SAMe, these high-potency NOW 400 mg SAMe tablets are a more practical choice for users on the high end of the range. We strongly recommend you take, at the least, a B-complex vitamin if you decide to use SAMe; the ideal B complex to use with SAMe is NOW's Homocysteine Regulator. These B-vitamin co-factors are necessary for your body to make full use of SAMe, but aren't supplied by the SAMe tablets themselves.
SAMe is a supplement formed in the body by an enzymatic reaction between adenosine-triphosphate (ATP) and methionine. It was discovered in 1952 in Italy and has been researched and manufactured there. SAMe works closely with folic acid and vitamin B-12 and functions as a methyl donor. This nutrient carries and donates methyl molecules necessary to facilitate the manufacture of DNA and brain neurotransmitters. * Tissue levels of SAMe are typically low in the elderly.
|Service Size: 1 tablet|
Servings Per Container: 60
|Ingredient||Amount||% Daily Value**|
| ** Percent Daily Value is based on a 2000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.|
† Daily Value not established.
Other Ingredients: Cellulose, Croscarmellose Sodium, Methacrylic Acid, Magnesium Stearate (vegetable source), Citric Acid and Ascorbic Acid.
As a dietary supplement, take 1 tablet daily, preferably on an empty stomach. Refrigeration is recommended after opening.
Individuals with bipolar (manic) depression should not take SAMe unless under professional supervision. CAUTION: Please discard the inedible freshness packet enclosed.