SAM-e
What is SAM-e?
SAM-e (pronounced “sammy”), or S-adenosylmethionine is a naturally occurring compound found in all living cells. SAM-e helps to manufacture hormones, neurotransmitters and cell membranes, and is involved in the structural formation of cartilage. SAM-e also plays a role in the production of glutathione, a substance used by the liver in the removal of toxins. Levels of SAM-e usually decrease with age, and are less prominent in individuals with depression or a B vitamin deficiency.
SAM-e has been studied for over 20 years in Europe , where in some countries it is classified as a prescription drug. It is considered a dietary supplement in the United States, however, and is not regulated by the Food and Drug Administration.
Health Benefits
Studies have shown that SAM-e may be effective for alleviating symptoms of depression, and within about 10 days, compared to the 4-6 weeks typical of selective serotonin reuptake inhibitor (SSRI) anti-depressants. Additionally, promising research shows that SAM-e may be effective for relieving symptoms of osteoarthritis, fibromyalgia and chronic fatigue syndrome.
Preliminary research shows that SAM-e may also help in the treatment of liver damage, migraines, and perhaps Alzheimer’s disease. More studies are needed, however.
Usage Indications
A general dosage recommendation has not been established, though exceeding 1600mg per day is not recommended. The effects of long-term usage of SAM-e are not known, but it has been shown to be safe for short-term use.
Choose the stabilized form of SAM-e, called “butanedisulfonate,” and make sure to buy enteric coated tablets for optimum absorption. The absorption of SAM-e is enhanced when taken with a B vitamin complex.
- Side effects: Rare, including skin irritation and gastrointestinal discomfort.
- Indications: Do not use SAM-e if severely depressed, or in the case of bipolar disorder (it will exacerbate the “manic” phase of this disorder). Do not take SAM-e if you are currently using an MAO inhibitor antidepressant.
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Product List for SAM-e |
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