SAM-e: Information

SAM-e (pronounced "sammy"), or S-adenosylmethionine, is a naturally-occurring compound found in all living cells. SAM-e helps to manufacture hormones, neurotransmitters and cell membranes, and is involved in the structural formation of cartilage. SAM-e also plays a role in the production of glutathione, a substance used by the liver in the removal of toxins. Levels of SAM-e usually decrease with age, and are less prominent in individuals with depression or a B vitamin deficiency.

SAM-e has been studied for over 20 years in Europe, where in some countries it is classified as a prescription drug. It is considered a dietary supplement in the United States, however, and is not regulated by the Food and Drug Administration.

SAM-e's Health Benefits

SAM-e provides wide-ranging health benefits, but most users are primarily concerned with one of 3 main functions of SAM-e. First, SAM-e is used to support a positive mood and state-of-mind. Studies have shown that SAM-e may be clinically effective for alleviating symptoms of depression within about 10 days, compared to the 4-6 weeks typical of selective serotonin reuptake inhibitor (SSRI) anti-depressant drugs. For this purpose, SAM-e can be combined with other supplements that promote positive mood such as St John's Wort.

SAM-e is also a very effective joint-support compound. Research suggests that SAM-e may be of value in relieving symptoms of osteoarthritis, fibromyalgia and chronic fatigue syndrome. In these situations it would be best to combine SAM-e with other joint-support compounds such as glucosamine.

Finally, SAM-e is also an excellent liver detoxification supplement, especially when combined with liver-support nutrients such as milk thistle and NAC.

Using SAM-e

A general dosage recommendation has not been established, though exceeding 1600mg per day is not recommended. Most people experiment with the dose of SAM-e to determine the lowest noticeably effective dose for ongoing use, usually 200-800 mg per day.

Side-effects and Cautions:

Rare, but may include skin irritation and gastrointestinal discomfort. Consult your doctor or pharmacist before using SAM-e if you are taking any medication or have a health condition.


2 Options from
$20.49 - $37.99
Save up to 55%

See Options

2 Options from
$17.42 - $35.99
Save up to 60%

See Options

Sale price $22.99
Save 42%

Add to Cart

Sale price $34.96
Free Shipping

Add to Cart

Sale price $29.99
Save 56%

Add to Cart

Sale price $26.40
Save 34%

Add to Cart

2 Options from
$16.90 - $27.99
Save up to 39%

See Options

Sale price $29.29
Save 46%

Add to Cart

* These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
MSRP means Manufacturer's Suggested Retail Price. There may not be substantial sales at MSRP
© 1999-2018, AllStarHealth.com | All Rights Reserved
Mobile Site